Hi, I’m Santosh D. Bhosale
Santosh D. Bhosale
Proteomics Scientist · AI/ML Drug Discovery · Scientific Project Leadership
A pharmacist-turned-proteomics scientist with a PhD and 15+ years spanning wet-lab mass spectrometry, computational proteomics, and AI/ML for drug discovery. Bridging deep domain biology with scalable data pipelines, client-facing insight generation, and project leadership.
Currently: Domain Expert - Scientific Project Lead at Persistent Systems — leveraging clinical and multi-omics data to drive patient-centric healthcare analytics and precision medicine engagements.
15+
Years Research
20+
Publications
1
Patent EU & USA
2×
Dissertation Awards
What I Do
Proteomics Meets Artificial Intelligence
Proteomics Research
Mass spectrometry-based proteomics (DIA/DDA), PTM enrichment (phospho, glyco, cysteine), biomarker discovery from serum/plasma, label-free & isobaric quantification.
AI/ML for Drug Discovery
LLM-based data extraction (Llama, Gemini, Claude) from ClinicalTrials.gov & PubChem, Python automation for biocuration, ML pipeline development, agile collaboration with data engineers.
Scientific Project Leadership
Domain expertise on patient-data healthcare analytics engagements — client communication, requirements definition, and insight generation, plus scientific project management, mentorship, and training of teams.
Experience
Career Highlights
| Period | Role | Organisation | Location |
|---|---|---|---|
| 2026–present | Domain Expert – Scientific Project Lead | 
|
Pune, India |
| 2025–2026 | Product Manager I – Growth | 
|
Pune, India |
| 2024 | Associate Scientific Manager |
|
Pune, India |
| 2023–2024 | Associate Biomedical Scientist | 
|
Los Angeles, USA |
| 2020–2022 | Postdoctoral Researcher | 
|
Odense, Denmark |
| 2018–2019 | Postdoctoral Researcher | 
|
Turku, Finland |
| 2012–2018 | PhD Researcher | 
|
Turku, Finland |
Research Output
Selected Publications
2026
Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile
2026
Modeling Synaptic Maturation From Growth Cone to Synapse in Human Organoids
2024
An Inflection Point in High-Throughput Proteomics with Orbitrap Astral: Analysis of Biofluids, Cells, and Tissues
2024
Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk
2018
Analysis of the plasma proteome using iTRAQ and TMT-based isobaric labeling
2018
Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis
2015
Serum proteomes distinguish children developing type 1 diabetes in a cohort with HLA-conferred susceptibility
Data Visualizations
Interactive Proteomics Heatmaps
Organoids · Celiac Disease
Mini-gut Organoid Proteomics
4,850 protein groups across crypt-like (ENRC) and differentiated enterocyte-like (ENRI) organoid states, cross-compared to human celiac disease biopsy markers. Companion data to Front. Mol. Biosci. 2024.
ECFCs · COVID-19
ECFC Proteomics — COVID-19 Severity
Proteomic changes in endothelial colony-forming cells exposed to serum from COVID-19 patients across four severity groups — asymptomatic to critically ill. Companion data to Int J Biol Sci. 2023.
Recognition
Awards & Grants
Doctoral Dissertation Award — Orion Pharma
€5,000 · 2018
Doctoral Dissertation Award — Maud Kuistila Memorial Foundation
€5,000 · 2018
Research Grant — Hospital District of Southwest Finland & Turku City
€3,500 · 2014
Travel Grant — ETH Zürich Proteomics Course
€500 · 2015 · Turku Centre for Systems Biology
Dr. Ashok B. Vaidya Prize — 1st Place, SAACCP Oral Session
2009