Santosh D. Bhosale
  • About
  • CV & Docs
    • CV (Web)
    • Resume (PDF)

    • PhD Thesis
  • Research
  • Blog

About

"From identifying proteomics biomarkers for disease to leading multi-omics biomarker platforms — the question hasn't changed, only the scale has."

Career Journey

From Bench to Bytes

My scientific journey began in proteomics, when I gained my first level of research experience with my master thesis in the area of proteomics and mass spectrometry. This led me to pursue PhD-level research in mass spectrometry-based proteomics — working at the intersection of analytical chemistry and computational biology to identify biomarkers, decode protein function and protein-protein interaction networks.

Over the years I worked across the full breadth of proteomics — from disease biomarker discovery in serum and plasma, to cellular proteomics, protein-protein interaction studies and PTM-specific platforms spanning phosphorylation, glycosylation and cysteine modifications. I also designed and taught practical proteomics data analysis courses, translating complex computational workflows into accessible training for the next generation of researchers.

Today, I channel that foundation into patient-data driven healthcare analytics, applying scientific and clinical domain expertise and AI/ML-driven approaches to multi-omics data to drive precision medicine and translational research initiatives.

Deep Expertise

What I Actually Know

🔬 Mass Spectrometry & Proteomics
  • LC-MS/MS experimental design & data acquisition
  • Database searching (MaxQuant, Mascot, Proteome Discoverer)
  • Label-free and TMTquantification
  • Post-translational modification (PTM) analysis
  • Protein complex & interaction network mapping
🤖 AI, ML & LLMs
  • LLM prompt engineering & pipeline integration
  • ML model application for biological data
  • AI-assisted biomarker candidate scoring
  • Data curation and ETL for omics workflows
  • Python & R for ML pipelines
  • Evaluation frameworks for model outputs in science
📊 Bioinformatics & Statistics
  • Multi-omics data analysis
  • Statistical analysis for high-dimensional biological data
  • Differential expression & enrichment analysis
  • Data visualisation
  • Reproducible pipeline development in R & Python
🚀 Product & Leadership
  • Biomarker module architecture & product management
  • Cross-functional team leadership (science × engineering)
  • Scientific communication for non-technical stakeholders
  • Agile delivery in research-product environments

Explore Further

Work & Resources

📄
PhD Thesis
The full scientific foundation — mass spectrometry-based proteomics research in depth.
Read PDF →
🎓
Academic CV
Publications, conference presentations, education, awards, and full research history.
View CV →
💻
R Scripts & Code
Open-source pipelines for proteomics analysis, statistical modelling, and omics workflows.
View on GitHub →
✍️
Blog
Long-form writing on proteomics - snapshot of previous publications.
Read Posts →